Dysprosody Differentiate Between Parkinson's Disease, Progressive Supranuclear Palsy, and Multiple System Atrophy
نویسندگان
چکیده
Parkinson’s disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA) are distinctive neurodegenerative disorders, which manifest similar motor features. Their differentiation is crucial but difficult. Dysfunctional speech, especially dysprosody, is a common symptom accompanying PD, PSP, and MSA from early stages. We hypothesized that automated analysis of monologue could provide speech patterns distinguishing PD, PSP, and MSA. We analyzed speech recordings of 16 patients with PSP, 20 patients with MSA, and 23 patients with PD. Our findings revealed that deviant pause production differentiated between PSP, MSA, and PD. In addition, PSP showed greater deficits in speech respiration when compared to MSA and PD. Automated analysis of connected speech is easy to administer and could provide valuable information about underlying pathology for differentiation between PSP, MSA, and PD.
منابع مشابه
Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3.0-Tesla MR imaging
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